• Vi­su­al­iz­ing In­trons

    Pic­tures Con­sid­ered #58 by Christoph — When we talk about genes and genomes to­day, we al­most re­flex­i­ve­ly thinks of long strings of the let­ters G, A, T, and C. And by read­ing se­quen­ces, we ea­si­ly de­tect stret­ches that code for pro­teins. We de­tect pro­mo­ters, tran­script­ion fac­tor bind­ing mo­tifs, start/stop sig­nals for tran­scrip­tion, sig­nals where in­trons are re­moved by splic­ing from pri­ma­ry tran­scripts... 

  • On Find­ing Jew­els in the Junk

    by Christoph Weigel — In prokary­otes, it only takes a small jazz band to get the mu­sic groov­ing: pi­ano and a rhythm sec­tion suf­fice. The pro­moter re­gion of a gene is a tiny stage on which RNA poly­merase ℗ and few tran­scrip­tion fac­tors (dr, b) im­pro­vise on a tune, i.e. they ini­ti­ate or skip tran­scrip­tion. By con­trast, it takes a big band in eu­kary­otes to per­form Duke Ellington's 'Car­a­van'. And since not all the mu­si­cians...