• A Model for DNA Seg­re­ga­tion in 1963

    Pic­tures Con­sid­ered #32 by Nanne Nan­ninga — The clas­sic pa­per on 'The Reg­u­la­tion of DNA Repli­ca­tion in Bac­te­ria' by Ja­cob et al. (1963) in­cluded a model on bac­te­r­ial DNA seg­re­ga­tion. In ret­ro­spect the model had far reach­ing con­se­quences which can still be felt to­day. It en­tailed a re­search pro­gram that in­spired many sci­en­tists. Yet, the model was not the main topic of the pa­per.

  • Ad­her­ing To The 'Repli­con Model' The Sloppy Way

    by Christoph — Sixty years ago Ja­cob, Bren­ner and Cuzin de­vised their 'Repli­con Model', in­spir­ing and use­ful guide­line for repli­ca­tion re­search ever since. Ac­cord­ing to the model, a 'Repli­con' is a ge­netic el­e­ment repli­cated from a sin­gle 'Repli­ca­tor' – repli­ca­tion ori­gin, in mod­ern terms – and repli­ca­tion is trig­gered by a pos­i­tive trans-act­ing fac­tor, the 'Ini­tia­tor'…