by Christoph — Just to quote myself here: When microbiologists describe a previously unknown bacterium, they are mainly interested in its lifestyle, metabolism, morphology and cell cycle. And to continue with the self-quotation: For me, "getting to know" newbies always involves finding out how they initiate the replication of their chromosome(s)…
by Christoph — When microbiologists describe a previously unknown bacterium, they are mainly interested in its lifestyle, metabolism, morphology and cell cycle. For me, "getting to know" a newbie always involves – let's call it an addiction – reading its genome sequence and finding out how it initiates the replication of its chromosome(s).
by Christoph — Sixty years ago Jacob, Brenner and Cuzin devised their 'Replicon Model', inspiring and useful guideline for replication research ever since. According to the model, a 'Replicon' is a genetic element replicated from a single 'Replicator' – replication origin, in modern terms – and replication is triggered by a positive trans-acting factor, the 'Initiator'…
