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Small Things Considered
  • Evo­lu­tion of a Su­per­pathogen

    Evo­lu­tion of a Su­per­pathogen

    March 16, 2015December 13, 2025

    by S. Mar­vin Fried­man — The en­ter­obac­terium Yersinia pestis, the causative agent of the plague, was re­spon­si­ble for many ter­ri­fy­ing out­breaks over the course of recorded his­tory, but the most dev­as­tat­ing pan­demic was known as the Black Death. Oc­cur­ring be­tween the years 1347 and 1351, it is es­ti­mated that it claimed about one-third of Europe's pop­u­la­tion, half of that of China, and one-eighth of Africa's. This dreaded dis­ease...

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  • TWiM #80: Hurl­ing Fleas and De­signer Chro­mo­somes

    TWiM #80: Hurl­ing Fleas and De­signer Chro­mo­somes

    June 13, 2014February 5, 2026

    Vin­cent, Elio, and Michele dis­cuss how to syn­the­size a de­signer yeast chro­mo­some, and de­ci­pher­ing the ge­netic changes path that al­lowed Yersinia pestis to be trans­mit­ted by fleas.

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