• Friend & Foe

    by Christoph — In a post two month ago, I re­ferred to 'de­fen­sive sym­bioses'. In a nut­shell: one or more sym­bi­otic bac­te­ria pro­duce a cock­tail of an­tibi­otics that pro­vide pro­tec­tion of a eu­kary­otic host against an ar­ray of op­por­tunis­tic bac­te­r­ial and fun­gal pathogens. I in­tro­duced the term not in con­trast but...

  • Even More An­tibi­otics In The Nurs­ery!

    by Christoph — We had learned ear­lier that Phil­an­thus tri­an­gu­lum bee­wolves – soli­tary dig­ger wasps that prey on bees, hence their name – em­ploy a "cock­tail" of nine dif­fer­ent an­tibi­otics to pro­tect their off­spring from detri­men­tal fun­gal in­fec­tions. The an­tibi­otics are pro­duced – I re­peat from the ear­lier post – by a bac­te­r­ial sym­biont, 'Can­di­da­tus Strep­to­myces phil­an­thi', which the...

  • Mi­cro­bial Read­ing Roundup

    by Daniel P. Haeusser — To­day I wanted to catch up with some re­cent books that vis­i­tors to this blog may have in­ter­est in adding to their mi­cro­bi­o­log­i­cal li­brary. So here is a roundup of six aca­d­e­mic mi­cro­bial ti­tles of note that make up a trio of re­lated pairs.

  • Fol­low Your Nose...

    ...To­wards More Eco­log­i­cal An­timi­cro­bial Ther­a­pies
    by Roberto — The re­mark­able trans­for­ma­tion in the con­trol of in­fec­tious dis­eases by an­tibi­otics is one of the glo­ri­ous sto­ries in mi­cro­bi­ol­ogy. But now, al­most in­sep­a­ra­ble from their dis­cov­ery and ap­pli­ca­tion, is its nasty se­quel, the rapid evo­lu­tion of an­tibi­otic re­sis­tance. We con­tin­u­ally read re­ports of the dire pub­lic health sit­u­a­tion that we may...

  • Mak­ing Mu­tants – And Watch­ing Them "In the Mak­ing"

    by Christoph — Hav­ing stud­ied the fa­mous Luria-Del­brück ex­per­i­ment from 1943, you know, as a ge­neti­cist, how to "make" an E. coli strain re­sis­tant to the strep­to­mycin: grow cells to late-log phase in a flask, with­draw 1 ml of the cul­ture, spread 0.1 ml aliquots on sev­eral agar plates con­tain­ing 20 µg/ml of the an­tibi­otic, and in­cu­bate the plates overnight...