Tal­mu­dic Ques­tion #89

Of the ~1030 prokary­otic cells on Earth, what pro­por­tion would you guess are vi­able (us­ing your fa­vorite cri­te­rion for vi­a­bil­ity)?

 

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Jason
14 years ago

If we as­sume that the pop­u­la­tion of cells is con­stant (10^30) and each cell can di­vide into two cells, then one of those two must die or the pop­u­la­tion of cells will rise. Con­versely, one of those two must live or the pop­u­la­tion of cells will lower.
So, I would guess that about 50% of cells are vi­able if abil­ity to repli­cate in the given en­vi­ron­ment is the mea­sure of vi­a­bil­ity.
If a cell is con­sid­ered vi­able if it will repli­cate given ad­e­quate nu­tri­ents, then 99% or more are vi­able, since per repli­ca­tion mu­ta­tion rates are said to be some­where from 1 in 100 to 1 in 1000.
Elio replies: Nice ar­gu­ments. Thanks a lot.

Doug
14 years ago

Where vi­able means "not dead", the pro­por­tion is prob­a­bly 100%. Where vi­able means "con­tains in­tact DNA", the pro­por­tion is ar­guably around 500%. Might just as well ask "How long is a piece of string?"
Elio replies: That's the idea be­hind Tal­mu­dic Ques­tions, they al­low you to set your own de­f­i­n­i­tions. So, as­sume what­ever length you want for the piece of string. By 500% what do you mean? What's the de­nom­i­na­tor? Shouldn't that be 100%?

Doug
14 years ago

What is "vi­a­bil­ity" — the abil­ity of the whole or­gan­ism to re­pro­duce or the sur­vival of a genome (with ad­e­quate po­ten­tial to be trans­mit­ted to an­other or­gan­ism)? I ad­mit it is a bit of a stretch to ar­gue that a chunk of DNA large enough to be con­sid­ered as rep­re­sent­ing a spe­cific or­gan­ism would be able to sub­vert a pas­ing mi­crobe. How­ever, a pass­ing mi­cro­bi­ol­o­gist could fa­cil­i­tate that event. Hence the ar­gu­ment can be re­duced to that of what % of a genome is re­quired to de­fine an or­gan­ism. Then one won­ders how long that %age would re­main once self-repli­ca­tion of an or­gan­ism has been in­ac­ti­vated. In this ar­gu­ment, the to­tal num­ber of "vi­able" mi­croor­gan­isms is >10e30 by a fac­tor which I chose to ar­gue is 5x but with no ba­sis for that num­ber what­so­ever (other than a spe­cious gues­ti­mate of the min­i­mum genome size of a bac­terium).
In the end, the an­swer to the ques­tion must be 100% since the mea­sure­ment of to­tal num­bers will in­clude a de­f­i­n­i­tion of what con­sti­tutes an or­gan­ism. This de­f­i­n­i­tion must be based in DNA and such DNA can be re­cov­ered, am­pli­fied, and re­stored to a self-repli­cat­ing con­di­tion.

qetzal
14 years ago

I like Ja­son' steady-state analy­sis, too, ex­cept I think there's an­other fac­tor to con­sider. How long does a dead cell per­sist?
I think the per­cent­age of live cells will de­pend on the degra­da­tion half-life of the dead cells (i.e. the time it takes a dead cell to de­grade to the point that it no longer counts as a cell at all).
If the degra­da­tion half-life is the same as the gen­er­a­tion time, then there should be 50% live cells. If the degra­da­tion time is longer (shorter), the per­cent­age of live cells should be lower (higher) than 50%.